Cross-draw is very comfortable, but not very concealable, for me. I have a Haugen Leather lefty cross-draw, for the SP101, a righty Kramer Crossdraw Scabbard for the GP100, and a Galco for the 1911.
A well-balanced shoulder rig comes to mind. This is crossdraw; just a little higher on the body. Not all climates are equally-suited to such rigs.
What about AOWB? A J-Frame, in just about any decent vertical scabbard/holster, should be about as comfortable as belt-level carry can be.