Being a DA/SA fan, I've owned both the HK45c and USPc .45. Both were reliable but I found the ergos a little challenging on both. I'd say I liked the HK45c a little better overall, but the DA trigger was horrendous... and the slick, flat grip wasn't exactly a treat to the hand. Traded it for the USPc .45... trigger was much better, but the ergos were worse--for me, anyway. I have small hands, so the depth of a .45 grip often presents a challenge.
For my compact-ish .45...
I have a Sig P245. It's very accurate in my hands, reasonably compact (enough to hide the grip in casual AIWB, w/o a fancy AIWB holster) and has been reliable. And I can reach the trigger okay. Obviously, they don't make the P245 anymore (like most guns I like, it seems). But P220 compacts were available up until fairly recently. They have the short grip frame of the P245 and have the same upper as the P220 carry.