Yes. In 2014, I attended an op sec training practical fundamentals class. We had two different shooters using two separate lots of freedom munitions reloaded 9 mm experience squibs. After one of the two shooters experienced a second squib they were told they needed to change ammo to continue the class For safety reasons. Luckily the majority of the class was shooting 9 mm. Myself and several other shooters gave them spare ammo so they could finish the class. It was definitely a distraction for the rest of the class.
I attended another local class where a shooters 45 ACP reloads would not run in his Kimber 1911. He was the only 45 shooter in the class so we had to run to academy during the lunch break and buy some Monarch Steelcase to finish the class.
It was a combination handgun/carbine class. Not surprisingly the same shooter's Homebuilt AR would not function either. This is more a matter of not vetting the gun and ammo before training. Unsurprisingly, the guy next to me with the Glock 19, 6920, and Wolf Steelcase 9 mm and 223 had no issues.