The HK USPs full size, USP45s in particular, work much better for me than "ergonomic P30s and HK45s.
The more rectangular grip with courser texture resists twisting forces better than the ergo grips with finer texture.
I have fairly hard bony XL hands without a lot of padding so I may be the 1/10th of the population the USP45 was designed for.
Of course when I was at Rogers I had skateboard tape on my Gl17.
The ergo guns feel more comfortable in the showroom but give me less control.