I would add that you can get out of the holster and in action quickly under bad circumstances but I suppose that goes along with shoots best.
A guy got mauled on Afognak about a decade ago and I happened to be in Kodiak town and talking with a good friend of his. Guy was apparently a terrific shot with his heavy revolver but never got the hammer strap off.
Most people with heavy revolvers are terrible at actually using them but not all. Some people love shooting them and they're downright fantastic shots with them as a result. But they're difficult weapons to both secure and deploy quickly under field conditions.