It may be different for different people, but a G21 has noticeably less recoil and muzzle flip in my hands vs a .40 such as a G22, or at least it feels like it. This seems to be supported by the fact that I objectively shoot .45 better, when measured by accuracy and splits. I’ve always found .40’s recoil to be snappy and slightly more difficult to control compared to .45 in a G21 or USP, particularly in rapid fire strings. It’s my understanding from GJM and others that the Gen 5 .40 Glocks have successfully remedied this issue, but I haven’t had the opportunity to shoot a Gen 5 in .40 S&W.
I guess I really don’t have much use for .40, though obviously it’s a well performing cartridge. For outdoors use I’d rather Lost Hills’ 250gr hard cast +P load, and if I felt the need to bump it up even more I’d just load my USP 45 with .45 Super.