The .45 ACP, even the +P versions are simply low drama setups in my experience.
They just tend to run and run. As compared to the 10mm, they are substantially less finicky. When discussing non 9mm platforms, the Glock 21, or HK USP simply will function under a wide variety of conditions and will hold up to an extremely high round count.
Most my experience (in .45 ACP) outside the 1911 centers around the G21 (with a good bit of time on the G30 series). The various G21s will handle a substantial round count, are accurate beyond most people's ability or reasonable expectations, and require extremely little in terms of maintenance.
As far as field performance, the heavy .45 slug is one that has been getting it done for well over a century. Essentially the formula of a heavy for caliber .44 or .45 from the low 900s to around 1,000 FPS has been killing all manner of man and beast since the Indian Wars, the Philippine war in the late 1800-early 1900s , the Pancho Villa Expedition, etc. The formula has been killing American Buffalo (Bison), mounted soldiers and their horses, Grizzlies, you name it.
It was used in the original U.S. Army issued .45 Colt revolvers as a black powder load. Now you can get essentially the same performance in a semi auto pistol that is easier to shoot, and has a substantially higher on board capacity, with a much faster reload, though I don't think reloading is overly important in most field incidents.
My own personal experience has shown that the heavy slugs will punch right though heavy bones and muscle. It does not rely on expansion and penetrates in feet rather than inches. It does not get the press these days as most don't know anything about high performance .45 ammo. They simply know the old 230 grain ball ammo which is usually doing 750-800 FPS. Heavy 250 flat point hard casts at over 900 FPS are a whole other animal.
They are by far my favorite field load, as they are right at that "Goldilocks" sweet spot in terms of recoil and fast, accurate shooting. More often than not these days, when I grab a handgun for carrying in Grizzly country, it is a .45 with heavy loads.
Lost River pretty much hit the nail on the head. The 45 has very little drama and tends to get the job done very well. I carried a Glock 21 (Third generation) for over 15 years as my primary duty gun. I shot something in excess of 32,000 rounds through that gun. While I had significant parts replacements, I cannot ever recall having a malfunction. When I wander the backwoods of Montana, a stainless Colt 1911 Competition Government Model is my odds-on choice for a people/grizzly gun (I usually have a rifle or shotgun handy as well).