This is one of the most thought provoking threads Ive read in a while. I think my initial thought would be in the face. I then look at the target which I would not have the luxury to study in a real scenario and realize I would probably shoot them in the hand. All of the stuff you normally want to poke holes in is covered by a gun or arm or hands. At that point penetration comes to mind. Are the bullets able to go through the bones to get to important things? I normally think of ribs and meat and this adds a few layers of bone.