In class I see mounts failing far more than the optics themselves.
A good first step is to understand how thread lockers work:
https://pistol-forum.com/showthread....er-information
...because a lot of people out there have absolutely no idea what they are doing. They mean well, but they are hopelessly wrong.
Once you understand a bit about how fasteners and thread lockers work, you know what variables you need to control.
Re-examine your cleaning process prior to mounting. Whatever thread locker you use, it's crucial that you carefully degrease and decontaminate the threads both in the hole and the fastener. When it comes to removing old thread locker and other gun, I find pipe cleaners really kind of suck. I've taken to using precision brushes from McMaster-Carr:
https://www.mcmaster.com/4905A12/
https://www.mcmaster.com/4754A782/
...because they are small enough to fit inside the threaded holes on most slides and durable enough to allow you to actually scrub well enough to remove a bunch of crud.
So if you handed me your gun and asked me to re-mount things here's what I'd do:
1. Obtain new fasteners for the plate if at all possible.
2. Using a dropper or something similar, put some 99% isopropyl alcohol in the screw holes of the slide and let it sit for a couple of minutes.
3. Using the precision brushes linked above, scrub the living bejeezus out of the screw holes in the slide. This will probably destroy the brushes...but I'm fine with that.
4. Use some compressed air to blow out the holes, then go back to steps 2 and 3 a few times.
5. While letting the slide dry, get a small tray or an old bit of tupperware you don't care about and put enough of the isopropyl alcohol in the tray to soak the fasteners. Let them soak for a few minutes.
6. Using a toothbrush and some tweezers, give the fasteners themselves a good scrubbing. (Note - I wear nitrile gloves when doing all of this to keep oils from my skin from being a problem)
7. Set the fasteners out on a clean shop towel or something to dry.
8. Once the threaded holes and fasteners are completely dry, I will apply a little Vibra-Tite VC3 on the threads of the fasteners. I will use a fine paintbrush (that has been cleaned in the alcohol) to force some of it into the recesses of the threads. Let this sit for 5-10 minutes.
9. Apply a drop of VC3 into the threaded holes in the slide. The drop will sit at the very top and not go down into the blind hole unless poked with a toothpick or metal pick to allow the trapped air out.
10. Affix the plate to the slide and then begin to thread in the fasteners.
If you've used the right amount of thread locker, a little bit of it will start to ooze out around the head of the fastener when you torque it down. This is key, as it helps hold the fastener in place as well. A good application fills in the gaps between the thread surfaces and any small gaps between the screw head and the slide.
11. Clean up any excess or spillage that happened on the slide. (Q-tips, paper towels, etc)
12. Set the slide somewhere it won't get subjected to temperature extremes for at least 24 hours.
Using that exact process I've mounted optics to my shotguns and to multiple Glock MOS pistols
without anything coming loose for literally thousands of rounds of shooting. I've set my Glocks aside in favor of running my customized M&P's, but prior to that they went through just shy of a combined 25,000 rounds without the plates budging an iota.