You don't have to change anything on a G21 (specifically a gen 2 in my case) for that load?
The ballistics look like those for a +P load. How often would one need to watch over parts and be ready to replace them if that load is shot often (and I'm not sure what shot often would translate to in terms of actual rounds so any extra info would help).
ETA: any change in the POA/POI?