Saddest thread I have seen in a long while. Like many here, I have very much enjoyed watching Astro frolic in the Alaskan wilderness. Thank you for sharing that happiness with us. I can't believe we don't have a vet in our forum. Christmas is about hope, and here is a small ray. At least from what this unscientific mind has been able to read, dementia and elevated liver enzymes do not necessarily go together. A dog can have dementia all by itself, but that is not what is happening here. Maybe if your vet can knock out whatever is causing the elevated enzymes, then Astro's cognitive health gets better. That's my hope and prayer.