A plain vanilla Ruger SR22 gets used more often than any other .22 pistol on the property. Being what it is - light, small and possessing a stiff trigger - it is not conducive to pinpoint accuracy... but when "sort-of" benched and fussed with, it isn't all that bad. With CCI Mini-Mags, it is as reliable as we could ask for. After a few years of use, the original magazines are still humming along even though they looked laughable right out of the box.
It is so blessed easy to care for that about anyone can take it down and clean it quite thoroughly. Fun... lots of fun (did I mention fun?) and a lot of trainer/plinker for the money. It may get little respect from the cognoscenti, but I likes 'em.
(N.B. If I had to feed myself with a .22, I'd probably want a Ruger MkII, III or some flavor of Buck Mark.)