I was serious on using a decent 165 and the 4350 load as it's a longtime winner. As for .45 ACP hardball, I think it generally sucks for shooting folks. I know that's likely to get me banned, but I've seen several uses of it, both intentional and not so that were really poor. Two of them, a pair of 14 year old girls, shot by one of their fathers with Remington ball a total of seven times in their chests and abdomens, were sitting on the curb, fully conscious, answering police and paramedic questions.