Erecting a new Alzheimer's Treatment?

[Nephrology]

Definitely.

I think it will be interesting to see if the plaque hypothesis gets walked back in the next few years. Especially in light of findings that will undoubtedly come with wide-spread proliferation of single-cell ATAC. Already seeing databases for combining those results - will take another couple of years for the informatics studies to catch up.

Could be wrong, but we'll see.

With aducanumab approved and another similar drug on the way if anything I am worried it will stick around. It is literally the only endpoint that demonstrated any significant difference in the trial.

I just think we haven't a clue. When I was still doing my PhD scRNASeq was the new hotness. I think in bio world we end up like getting a new hammer and everything is a nail. I think with a lot of disease research where we've made almost no progress (Alzheimers is a good one) we need to be thinking wildly outside of the box and starting from ground up. I am not smart enough to do that but we need people who are.

[Lost River]

True story...

A bunch of us were in a land far far away. We were waiting in an airport for flights, outbound for home, with part of us heading for Washington Dulles. The others for flights that would take them eventually to Amsterdam. A few of the guys were fairly well lubricated. One of our teammates was well known for bumming things off of others and never having any money on him in spite of making a ridiculous amount of money and having no real bills. He was heading for Amsterdam.

He was the kind of guy who would go on break from what we did, be gone for a month, come back and we would find out he had been living on a beach in Costa Rica, and he had spent 50K there during that time. "Oh and hey would you mind buying the pizza, I am broke.".

We will just call him "Sleeve" due to the tats. Anyways, Sleeve, starts asking around hitting guys up for sleeping pills for the flight. Nobody has any for him. Except one of our other teammates who happens to be a serious prankster. Prankster says, "Sure take a couple of these once you get on the plane.". Except they aren't sleeping pills. They are Viagra.

Sleeve decides the best thing to do is get quite smashed drunk right before getting on the plane, then once on board, pop his "sleeping" pills and then he should be able to sleep all the way to Amsterdam. Things did not go so well for poor Sleeve. Apparently being piss drunk, he could not hide the results of the boner pills from the female flight attendants and good times were had by all (except sleeve).

Sleeve never again bummed any more pills from anybody after that as far as I know.

[the Schwartz]

It sounds like your fellow teammate was a bit hard on "Sleeve".


Sorry. Couldn't resist.


I'll go sit in the corner now.