COVID-19 vaccines: medical concerns and recommendations

[YVK]

Friday news dump:

An FDA advisory panel voted 18-0 to recommend Pfizer boosters for those 65+ and those with high risk or occupational exposure. If the FDA follows the panel's recommendation, qualifying patients could get a booster 6 months after their 2nd shot.

The same panel voted 2-16 - i.e. against - recommending boosters for the general population citing concerns a third dose might cause additional instances of myocarditis in those under 18. They wanted more data than was available at this time from the 300-person Pfizer booster trial or 3-million person Israel booster report.

I have no time to look or review the source data. From what I remember off the top of my head, their votes didn't meet my own internal consistency test.

[0ddl0t]

I have no time to look or review the source data. From what I remember off the top of my head, their votes didn't meet my own internal consistency test.

If you find yourself with 8 hours to kill:




materials:
https://www.fda.gov/media/152243/download




Emphasis mine:




Because we distributed vaccines to older populations first, it is hard to see enough data on 6+ month vaccine efficacy in younger populations. The fact that we have delta now vs alpha confounds things further. Knowing what I know at this point, I'll personally be getting a booster at 6 months (as a healthy ~40 year old)

[cheby]

I have no time to look or review the source data. From what I remember off the top of my head, their votes didn't meet my own internal consistency test.

Careful, I got yelled at by the gun forum medical expert just for asking a question about this

[TGS]

Careful, I got yelled at by the gun forum medical expert just for asking a question about this

Want some salsa for that chip on your shoulder?

[cheby]

Want some salsa for that chip on your shoulder?

I am glad you got the message. How are you doing?

[TGS]

I am glad you got the message. How are you doing?

If you think I was presenting myself as a medical expert, or that I yelled at you.....I guess I'm doing more emotionally healthy/stable than you are.

[Borderland]

Friday news dump:

An FDA advisory panel voted 18-0 to recommend Pfizer boosters for those 65+ and those with high risk or occupational exposure. If the FDA follows the panel's recommendation, qualifying patients could get a booster 6 months after their 2nd shot.

The same panel voted 2-16 - i.e. against - recommending boosters for the general population citing concerns a third dose might cause additional instances of myocarditis in those under 18. They wanted more data than was available at this time from the 300-person Pfizer booster trial or 3-million person Israel booster report.

I'll be getting a booster next month. That will be 3 shots this year while 46% of the eligible population hasn't had any shots. I'm not doing it for anyone but myself and my wife and the fact that if I do get covid I likely won't be taking up space in the hospital for someone that wasn't smart enough to get vaccinated.

[0ddl0t]

Speaking of vaccination rates, here are 2 more slides on that subject that I found interesting:






(it seems odd to me that those aged 65-74 have a higher vaccination rate than 75+ )

[YVK]

If you find yourself with 8 hours to kill

A projected time frame for that is the second half of 2035

I'll personally be getting a booster at 6 months (as a healthy ~40 year old)

Well, if FDA wins this one, as a healthy 40 year old you can't have it .

Seriously though, since they have spelled out a concern about uncertain risk of a myocarditis, I wonder if vaccine providers will be willing to take any liability risks by giving boosters to "unapproved" groups. Obviously, boosters in such groups would be totally voluntary but the liability climate here is such that providers may choose not to bother.

I am nearly sure that they will carve out some exception for health care workers. As a healthy 50~ year old over 8 months post, I am sitting tight until I see a rise of severe breakthrough infections in healthy 50 year olds, or boosters show clinical outcomes, or delta booster is here.

[0ddl0t]

They did recommend boosters for anyone in a high risk occupation (not defined), as well as those with health conditions.

Basically they felt the most compelling reason for the general population to get the booster was to prevent infections, but they rejected the prevention of infections as a priority given that T & B cell responses seem to still be doing a good job preventing serious disease in most breakthrough infections. They would rather focus on vaccinating the unvaccinated (and don't seem to think you can do both).

With the rare incidences of myocarditis after shot #2 in those under 29 and the very low risk of serious disease in that age group, they also did not think it was appropriate to open boosters up to 16 year olds at this time. They indicated they would prefer to see a staggered approach while they collect more data on booster safety.