YMMV
Outside of the realm of previous mentioned physical security equipment/technology layers, at the last defense personal level, I'd probably work up for a female in my family in this scenario, a system of OC spray and a small fixed blade knife with a great concealment and access rig. Now the females in my family all possess "the spirit of the bayonet" when it comes to self defense so there is that to consider.
The old dictum that knives "aren't much use without the training and reflexes of a Green Beret" . . . I called BS on that the first time I read that in the '70's or '80's.
YMMV and I could be FOS. But I don't think so.