Likely depends on where. I was a frequent spider bite (and biting tree ant) victim. Spiders made me blow up much like the OP's photo. Round, swollen, warm to the touch. Cortisone cream was the solution most of the time. Frequently the center of the bite would get black (necrotic?) and weep for several days. Debriding and Neosporin with lidocaine worked well there.
Also, the timing is an indicator. If you think you got a bite today and it looks like that, it's not likely Lyme. Lyme rash takes at least a few days to show up.
https://www.mayoclinic.org/diseases-...s/syc-20374651
Spreading over days is also a Lyme indicator. Quickly resolving same-day with cortisone causes me to think spider or insect more than Lyme as well.
FWIW. Not a Doc but frequently bitten.