I'm using my Ruger MKIV Target with an MRDS to get in some live fire practice during the centerfire ammo draught.
I had a Holosun HE507C-GR X2 on a Maddmacs low profile center base (http://maddmacsprecisiontactical.com/) as the starting point. The Ruger factory sights weren't tall enough to balance the dot on the front sight, so I searched the web for replacements. Ruger had a taller set of night sights, but I didn't need the tritium capability. Looking further, I found Kensights (https://stores.kensight.com/), a company in Georgia, with several choices for taller sight for the Rugers.
I bought the black target set (front & rear) after chatting with their customer service about my needs (GREAT customer service, BTW). When they arrived, they were easy to mount in place of the factory sights, and allow me to balance the dot on the front sight just like my G45/RM06 with suppressor sights.
It would work as well, or better, with an RMR on the same Madmaccs base.