I watched this movie specifically because it featured a 4506. And if going through IMFDB to see what movies have certain guns I'm into is wrong... I don't wanna be right.
A few years ago, I was really into the big bore 3rd gens. At one point I had a 645, a 4566, a 1076 and two 4516-2s. The only one I still have is the 645. I had some arbitrary FTFs with one of the 4516s, the 4566 and the 1076. So, they kinda lost their magic to me. The 645, however, has never missed a beat. I had a 110 lb girl who'd never even seen a gun shoot it... it cycled fine. And it DOES cycle empty cases, as I've found.
I like the fact that the 645 has removable grip panels. The stock delrins on the 45XXs were a little
too thin for me. I have Pachmayrs on my 645--I find them sufficiently hand filling. That said, if you can find the palm swell delrin grips they used on the 1076, they're actually very comfortable. That's what came on mine. Damn I loved that 1076. I felt betrayed when it started jamming for no freakin reason. Sigh.
In the future, I probably wouldn't go for anything less than a 5 inch in a big-bore Smith. I'd like to get a 4506-1 at some point. I like it just because it's the ultimate in terms of beefy steel 3rd gen awesomeness--slightly thicker slide and a non-stepped frame, vs. the no dash.
All that said, I think I shoot a P220 better. But I don't think I'll ever sell my 645.