They are fine for .44 Mag but not .454 Casull. It's mainly applicable as to why S&W created the X Frame for the Godzilla Magnums and you won't see any .454 Casull N Frames. Meanwhile Ruger didn't have to worry about it in the slightest for their .454s and .480s in the Super Redhawk. Most folks don't think about it because the S&W frames are plenty strong enough for their chamberings and they just stop considering anything else. They get into trouble quickly when they try to make their Mod. 25 45LC into a .454.