Do you only have one primer pickup tube? Stopping to pull the pin out of the next primer tube every 100 rounds really only causes me a brief pause, but I have 5 of them and I fill them with a vibratory tool, so whenever I get to the point where the press and all of the pickup tubes are empty, I fill one, immediately fill the press from it, and then fill all 5 so that I can load another 600 rounds with only brief pauses. That whole operation really only takes a few minutes and then I'm back up and running.
It was definitely tedious when I only had 3 pickup tubes and had to actually do the primer flip tray/stab the tube at the primers to pick them up thing, though. The hand cramps were no joke, and whatever money I spent on the primer tube filler tool was worth it. (IIRC it was actually pretty cheap.)
ETA: This is what I use, and it makes life way better:
https://www.amazon.com/Frankford-Ars.../dp/B00BQ6A3Y0