i chose a gun that others have well tested, Beretta 92. i chose ammo that others have well tested, Hornady Critical Duty 135gr. combine, fire a few shots so i know how it feels, call it a day.
our wonderful military spent a fortune testing and sorting out the 92. our wonderful FBI spent a fortune testing and accepting the Critical Duty 135, including making sure it passed their barrier penetration tests. no point in redoing all that testing from scratch.
if you want to fire lots of rounds thru your gun to assure yourself that it's a good combo, go for it.