25k a year puts you firmly OUT of the Smith K-Frame territory and forget anything with a Pony on the side.
The only choices become 686 or GP100 for a medium framed 6-shot .357 gun. And these aren't going to handle 25k a year of Magnums, but presumably you're talking .38s and probably ones you're reloading to minimum power-factor. In that case you're unlikely to significantly wear a 686 or GP100 with 25k rounds. You may need to replace a firing pin/firing pin spring/main spring/extractor spring - but you're unlikely to develop endshake or excessive forcing cone erosion running light .38s in an L-Frame or GP100.
Otherwise you'll need to consider an N-Frame or Redhawk which are both huge guns (and 8-shooters at that). Plenty of ICORE guys have thousands upon thousands of rounds of light .38s through 627s. BUT most of those guys are running 160-grain coated bullets, loaded in .38 Short Colt brass (faster moonclip reloads) over a powder charge that is so light a bunny fart would blow it away.
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My 4" taper barrel GP100 has ~15,000 .38Specials and around 2,000 .357 Magnums through it. It has no measurable endshake, yoke stretch, forcing cone or top strap erosion, and has require nothing in the way of maintenance. In fact, I've mentioned it here before, I've never even taken it apart (I don't even know HOW). I run a bore snake through the cylinder and barrel, and brush under the extractor star after each range session. Every once in awhile I check to make sure none of the screws are loose. Every couple of thousand rounds I remove the cylinder and yoke to clean them, basically whenever opening the cylinder gets a little tough/sticky.
I don't know if that's "Glock-like" reliability, but it'll do for me. If I went to the safe and needed to grab a pistol I knew was going to hit where I aimed and work, I'd grab that GP100 and a handful of speedloaders. I know it's gonna drop 125-grain Gold Dots where I want them out to 50-yards without issue.
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That said, my gun is a ~2003-2004 manufacture gun. And I'm lead to believe that maybe the newer GP100s aren't quite as well made. I don't know, I've never needed another one. Though a 3" WC is on my 'want' list.
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And I know @jetfire loves that ACRO equipped Smith, but damn that thing is so ugly. I'm not sure a porkchop around it's barrel would get the dog to play with it.