DocGKR addressed this in his information on M4C....he didn't speak only to killing dudes through barriers. If I'm not mistaken, some departments choose loads like Mk262 specifically because of its poor barrier performance for room entries in urban neighborhoods. This is actually a tertiary factor that has influenced PD's in their switch from handgun-caliber SMG's to 5.56 caliber carbines general. He addresses this in his post that is extremely relevant unlike you claim:
Home Defense Long Guns
So, given that he claims Mk262 to have poor intermediate barrier performance, and the fact that 5.56 weapons in general offer reduced risk, I think you can deduce something very relevant to your question and it should serve as a good answer.Keep in mind that over the past 20 years, the vast majority of the 5.56mm/.223 loads we tested have exhibited significantly less penetration than 9mm, .40 S&W, .45 ACP, and 12 ga. shotgun projectiles after first penetrating through interior walls. Stray 5.56mm/.223 bullets seem to offer a reduced risk of injuring innocent bystanders and an inherent reduced risk of civil litigation in situations where bullets miss their intended target and enter or exit structures, thus 5.56mm/.223 caliber weapons may be safer to use in CQB situations, home defense scenarios, and in crowded urban environments than handgun service caliber or 12 ga. weapons.
If you need more than that to feel safe about using Mk262, there's a better article I think you could read:
The Presumptive Hazards of Over-Penetration
As Doc usually finishes, ammo choice is down the list behind training and developing a warrior mindset. You can choose a load with some reduced risk, but as F2S mentions it's still going to be a bad day. It might have a reduced chance of killed little Suzy, but if you miss and hit little Suzy, you've still shot little Suzy! There simply isn't a load available that will kill bad guys and only bounce off innocents. Mk318 SOST would probably be counter to your goals, but Mk262 is probably as good a load selection as you can make. The more important factor is training.