I run in downtown Seattle with a HPG runners kit and I feel it definitely stands out. There is a definite price to pay for the ergonomics and comfort in terms of "conceal-ability". If you are even little versed in CCW then it's obvious whats in my chest pouch. Sometimes I do 4-5am runs and do not care about being absolutely covert due to the majority of street people wondering around. I do wish they made the ripstop versions as a regular option and added loop to the back of the large compartment.
For day hikes I have a kit bag married to the tarahumara bag and feel it doesn't draw too much attention in the wilderness. I am revising that setup and probably sell that and run a hip pack with a regular daypack as I am not running through the wilderness so bounce is less of an issue and will blend in with other hikers better.