I have a P2000 V2 LEM in 357 Sig, came with a spare 40 barrel. I actually prefer the 357 Sig setup over the same gun with the 40 barrel; the 357 recoil pulse feels faster and sharper and comes back on target a little faster for me. I don't shoot either quite as well as my 9mm P2000 with the same trigger setup though, I'm slightly more accurate with 9mm (measured) and I think a bit faster (gut feeling). Oh, and while I don't particularly notice muzzle blast outdoors in daytime, at the indoor range the 357 is for sure more distracting to the guy next to me. There have been "what is that?" comments.
The original intent was to use it as a backcountry gun that was similar to my in town 9mm. After thinking it through though, there really aren't any ammo selections that are well suited to big animals, pretty much just JHP and FMJ, few heavy bullet options, even fewer non-lead options now that the California regs have kicked in for taking wildlife. So I moved to a USP45 for backcountry, or sometimes a big bore N-frame revolver.
That left the 357 Sig pistol without much of a niche. In town it's just a slightly faster 9mm, not a lot of difference in carry ammo cost but a bunch in practice ammo, and more finicky to reload. The P2000 was perfectly reliable in 357, I just don't see a lot of advantage to offset the practice cost. I have nothing against it, but feel like 9mm can get the job done effectively. Thus it sits in the safe, haven't fired it in maybe two years. Although I probably should use up the rest of the practice ammo, couple hundred rounds just sitting there.
I haven't seen another P2000 in 357 Sig for sale since I bought mine from a SoCal LE guy (suburb of San Diego, he said it had been his duty weapon for a while) five or six years ago, admittedly haven't really been looking. Barrels turn up sometimes and should drop in a 40.