Spent a long time carrying a 4506 on duty, bought it out when we transitioned to .40s. One of my all time favorites. My department doesn’t permit 1911s, but I may have carried one off duty from time to time...
A HK45c rode in my holster for a bit as a detective, and while I never carried a G21 at work, I have owned a couple. Tremendous pistols, just larger than what I now prefer to carry.
While lacking the panache of a German 220, I have carried (and still do dependent on what I feel a need for) a M&P compact .45, or the mid size. Both are the best of the bunch for M&Ps in my opinion, for what that is worth...