.300 BLK works well at the lower velocities only because the bullet manufacturers have engineered projectiles specifically to expand at low speeds, down to ~1350 fps in the case of the Barnes Tac-TX. Run it above ~2350 fps at impact and it starts shedding petals.
There was also a video discussed last year somewhere on this site where Federal engineers (the guys who keep polishing on HSTs) said you start seeing rifle-like tissue damage above about 2300 fps. So .300 BLK, at the top end of its velocity range, is just barely getting its toes across the line.