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Thread: Coronavirus thread

  1. #6391
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    Quote Originally Posted by whomever View Post
    I've been wondering since spring why HVAC wasn't getting more attention.

    Blog post from a UW prof on the efficacy of filters:

    https://cliffmass.blogspot.com/2020/...purifiers.html

    He links to a more in depth discussion from the EPA.

    We did the high-MERV filter+box fan thing when the smoke was bad this summer, and it seemed to work pretty well.
    Excellent timing for folks having guests for Thanksgiving. Looking at their website, Lowes doesn't have anything adequate in my sizes but HD does.

    Gonna be 72 and sunny here tomorrow. I'll be outside.
    "No free man shall ever be debarred the use of arms." - Thomas Jefferson, Virginia Constitution, Draft 1, 1776

  2. #6392
    THE THIRST MUTILATOR Nephrology's Avatar
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    Well ladies and gents, our shop is full. Like, totally full.

    Below is a chart detailing the census for our healthcare network's regional (metro area) hospital systems. Includes 4 hospitals total - the flagship plus 3 satellites (Sat 1, 2, 3; note that Sat 2 does not have an ICU).

    You'll note that in addition to basically all med/surg ('regular hospital') floor beds and ICU beds being full, fully >25% of all patients across all hospitals and bed types are COVID+. It's honestly not clear what we're going to do for new admissions, given that ICU rooms are already moving to double occupancy (and are still full).


  3. #6393
    Quote Originally Posted by TiroFijo View Post
    Any opinions on Merck's CEO Kenneth Frazier "You can’t rush science" commentos on COVID vaccines?

    Although logical, it seems there is a component of "Dang, we missed the boat!"...

    https://www.cnbc.com/2020/09/09/merc...s-vaccine.html

    https://www.cnbc.com/2020/10/29/covi...le-future.html
    Quote Originally Posted by JAD View Post
    Too bad you can’t make a vaccine out of sour grapes.
    The most ironic thing is that Merck is playing an ethics card, too fast may be not ethical. Ken Frazer's rise in the Merck started when he became a lead defender in one of the most unethical data manipulations cases by a pharma company in recent history that ended up costing Merck several billions in settlements. I believe the reason why he went up after that was because the projected losses were several fold higher so he was seen as a savior.

    Quote Originally Posted by David S. View Post
    Critique of the recent vaccine studies.

    What COVID Vaccine Hype Fails to Mention.
    I don't think the doc who wrote it, or anyone else in the peer community has hands on actual studies. I want to see them with my own eyes. Some of his critique is open to critique too. For example, 164 cases could have a been a prespecified count based on projection stats so by itself it doesn't tell much.
    Doesn't read posts longer than two paragraphs.

  4. #6394
    Quote Originally Posted by Nephrology View Post
    Well ladies and gents, our shop is full. Like, totally full.

    Same here. Hoping for Thanksgiving break to provide some relief (no elective cases) but only weakly so.
    Doesn't read posts longer than two paragraphs.

  5. #6395
    regarding the HVAC/filtration front, I've seen several points that may help:

    Higher MERV filters for either HVAC or box-fan hack. Seems to be MERV 13 is what is generally recommended. Can calculate how much airflow you're pushing through each box fan and you could scale up and try to aim for 3-6 air changes per hour for whatever space you're trying to keep "clean"

    Open windows if possible. Going outside is even better.

    40-60% humidity

  6. #6396
    Site Supporter farscott's Avatar
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    I know we discussed this before, but new information tends to change answers. And there are a lot of people contributing to this thread who work in the relevant fields or, at least, adjacent to the relative fields.

    Once we have one or more vaccines being used, will the vaccination be one-time for life, once every decade like tetanus/diphtheria, or once per year like the flu vaccines? In other words, is the virus mutating or does the vaccine effectiveness decrease over time? Is there enough evidence to even formulate an answer?

    Another question: Is there any evidence to suggest which one of the vaccines is the "best" one? And, if so, what makes it the "best"? With three (to my knowledge) candidates, which will go into mass production and mass adoption?

  7. #6397
    THE THIRST MUTILATOR Nephrology's Avatar
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    Quote Originally Posted by farscott View Post
    I know we discussed this before, but new information tends to change answers. And there are a lot of people contributing to this thread who work in the relevant fields or, at least, adjacent to the relative fields.

    Once we have one or more vaccines being used, will the vaccination be one-time for life, once every decade like tetanus/diphtheria, or once per year like the flu vaccines? In other words, is the virus mutating or does the vaccine effectiveness decrease over time? Is there enough evidence to even formulate an answer?

    Another question: Is there any evidence to suggest which one of the vaccines is the "best" one? And, if so, what makes it the "best"? With three (to my knowledge) candidates, which will go into mass production and mass adoption?
    1. We do not know how long the immunity provided by the vaccine will last, as by definition that has yet to be tested. However, coronaviruses do not mutate nearly as fast as influenzaviruses. Influenza viruses have a genome that is segmented and can be shuffled (like a deck of cards) between 2 strains of flu infecting the same host. It will not require a whole new vaccine to be designed, manufactured and distributed every year like we do with influenza.

    Beyond that I do not know for sure. Coronaviruses do accumulate mutations (like all organisms), but the vast majority of those mutations are not significant enough to change your immune system's ability to recognize it. I would imagine it is possible but a long-horizon concern. I would be more concerned about the emergence of a 2nd, totally different respiratory pathogen from a zoonotic source, myself.

    2. Current evidence suggests all 3 vaccines (moderna pfizer astrozeneca) are pretty comparable. all 3 use very similar technological approaches and all 3 appear to have 90% or greater efficacy from the current results of ongoing phase III trials. I am not aware of any reason to think one is materially better than the other. I have no idea what will happen re: distribution, production ,etc.

  8. #6398
    THE THIRST MUTILATOR Nephrology's Avatar
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    I do actually know one small piece of information - select healthcare workers will be getting one of the vaccines by Dec 10. My thesis advisor, for example, who is a MICU doc at our local county hospital that is also apparently a DoD designated Ebola center, will be getting his first shot that week.

  9. #6399
    Quote Originally Posted by Nephrology View Post
    I do actually know one small piece of information - select healthcare workers will be getting one of the vaccines by Dec 10. My thesis advisor, for example, who is a MICU doc at our local county hospital that is also apparently a DoD designated Ebola center, will be getting his first shot that week.
    We got an email today saying our agents will be able to get the vaccine mid-December. I hope that turns out to be true-- I plan on getting it.

  10. #6400
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    Working on plans here for vaccine distribution to front line clinical staff in December. (Not me personally, but my institution.)

    Regarding durability of vaccine-mediated immunity, 1-3 years is probably a safe range for a bet. I'm reading up on this topic this afternoon, but since the virus emerged less than a year ago, it really still is a guess. I agree with Neph about mutations. I'd be very surprised if that becomes a problem anytime soon.

    Sent from my moto e5 cruise using Tapatalk

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