Either way, I will probably end up with 240-250 grain loads at 1100-1200 fps out of a handgun with handloads . Maybe a bit more with a SRH, especially with an 8" barrel.
I doubt I will shoot much in tbe way of hotter stuff in a handgun. But I could see going boutique in a carbine.
For some reason, the only "cowboy caliber" I really lust for is .44-40, but I want it in an N-frame. No idea why. Modern .45 Colt strikes me as a different animal than the balloon-headed old round. I've never really picked up the SA addiction like I have for DA guns, despite owning a very nice Single-Six.