It will be a while before I buy a revolver in a higher powered chambering than .357 Mag, but when I do, it will probably be in one of the two cartridges listed in the thread title. I imagine a N-frame or Super Redhawk with a 5"+barrel, with a companion carbine. I would be solidly be in favor of of .45 Colt, but it limits my options, and it would mean I will probably never buy a .45 Colt Smith, as my personal policy is not to keep dangerous combos of ammo and guns that can chamber it in our house.
Assuming handloads, but with an eye to available factory loads, and use on light/medium deer, which one?