The weight difference between an empty pistol and one full of ammo doesn't cause any issues going from dry practice to live fire.
I doubt the weight difference between a loaded Glock 19 and a loaded rimfire clone would be a problem either unless there's some physical infirmity going on.
The value of correct dry fire practice has been validated by some of the best handgun shooters, bar none, in the world. The fact that some still find ways to question its value just makes me laugh.