Sure, that's where the "good enough" comes along. A bigger bullet will give you more leeway, a little more chance to sever that artery or spinal cord; there's also the argument of more KE gives you a bit more barrier penetration. Of course, as previously noted, that size difference is pretty minuscule, and quality bonded ammo of the three main calibers don't have that much difference when it comes to barrier performance (yeah yeah, there's always the rare scenario where the 9mm won't have enough KE after a barrier to penetrate a skull or something while a .40 S&W can), so... yeah.