Man, 3 pages into a discussion of a 10/22 for self-defense, complete with pics of a suppressed version, and mention of wheelbarrows and de-barked chihuahuas? I don't know whether this is a sign of the superiority of P-F.co over all those other internet gun fora, or a gross violation of internet gun forum norms.
FWIW and back on topic: Here in WA a 10/22 is an evil assault weapon. The only reason I can see for endorsing a 10/22 for self-defense here is that HH6 finds it marginally easier to manage a 10/22 than an AR. But she feels the same about her Keltec Sub2000. And her 20 gauge Coach Gun.