The smaller frame is a bit handier, and plenty strong for any reasonable .357 loading. The large frame guns handle well but are bigger than they need to be and, unless you're going to run red-line handloads, any additional strength or weight is likely unnecessary. If you need more power, then a larger caliber or a .357 Maximum is the way to go. The big difference; or, at least, the difference most likely to matter in day-to-day handling, is the alloy grip frame on the large-frame gun versus the steel grip frame on the small-frame gun. If possible, handle both before buying because the guns balance differently and will feel different in the hand.