My wife is fairly experienced but still somewhat fits in the above category. She tried Glocks and likes their simplicity but the "beavertail" bothers her thumb joint when shooting more than 15 rounds. Beretta 92 of different variants...the DA/SA thing was too much and the grip slices her thumb webbing. Together this is about 8 or more years of range time, trial and error, instruction etc...We've also tried the sig p238, Glock 26, and Glock 42. The 238 was closest to being acceptable but the lack of 3 finger grip was a no-go.
We've now gone to 9mm 1911s. So far so good...only problem is the weight. But its somewhat comparable to a loaded 92. The 9mm 1911 is easy to load, has a manual safety, can find ones that have triggers in the 5-7 lb range, and yes you can some that are reliable. And the accuracy is a huge benefit...she can get good hits on target at 15 yds much easier.