It depends on how much hand fitting/tuning if any is performed on the guns.
Colt offers a completely hand fit, hand tuned pistol with no MIM or cast parts. It sells for around $2200. Obviously more than a typical Dan Wesson pistol. But when a manufacturer whose pistols are mostly built on an assembly line offers a truly hand built gun it is going to cost more because the build process is an exception to their normal process. A Springfield Armory Professional is a hand built gun that contains some MIM parts and yet sells for over $3000. How does it compare to a Dan Wesson? It's subjective at that point.
If the Ruger custom requires a lot of hands-on work that explains the big difference in price compared to their regular guns.