A buddy really dug my 22LR LCR and decided he needed to have one of the plastic Rugers. Wound up with a 3" model in 22 WMR. He's broken both hands multiple times in work and play, screwed up his dominant wrist multiple times, has a worse dominant shoulder than support side, and is not getting any younger.
He plans to teach himself to shoot lefty with the LCR before his injuries finally force it and have a better than nothing chambering in a premptive "retired old fart" rig. A friend of his runs a brace of .22 Beretta Bobcats, one in each pocket, as a retirement set-up and even managed to avoid getting caught with them during an extended near-fatal hospital stay.
I'm currently saving for an LCR in 327 Federal Magnum to load with H&R Mags or 32 S&W Long wadcutters as a preemptive thing before I age. Watching what my father and older friends are going through, want to get myself a pocket gun lined up now. Also have a Glock 42 set aside with Defoor sights, mags, and holsters as it's such a soft shooter with relatively easy to rack slide.