When I broke my hand I had to carry left handed. I sucked fairly equally with all of my options. Once I had the new hardware in my hand and was doing physical therapy I was measurably better with a GP-100 than with a Glock 22*. My grip strength and dexterity were still limited and my fingers didn't move in the ways they used to. I found the rubbery grip and plow handle shape to be significantly easier to manage during that time.
*clarification: I mean once I could use my right hand again. I still sucked with everything left handed.