The best lefty reload is Michael de Bethencourt’s right-handed reload, which starts with both hands together, on the weapon, almost mirror-image positions of each other. Yes, I said that a lefty should use Michael de Bethencourt's right-handed reload. End the reload with the weapon in the right hand, and if necessary to fire immediately, fire right-handed. I am not kidding.
Think about it: During this reload, the left hand is handling the speedloader, Slow Strip, or loose rounds, so is doing the heavy lifting, from a dexterity point of view. Yes, the “right-handed reload” actually favors the dexterity of the left-handed person. The right-handed reload favors the dexterity of the left-handed person.
As for firing right-handed, immediately after the reload, well, again, think a moment. The need to fire immediately indicates a very-close-range shot. Very-close-range shooting is not a demanding skill, and the efficiency of keeping the weapon in the right hand, at that rushed moment, trumps precision accuracy, in my opinion. It firing immediately after the reload is not necessary, then, transfer the weapon carefully to the favored hand.
Lastly, train out of this handedness thing. There should not be a “weak” hand, with snub-guns, at close range. I can understand the desirability of maximizing long-range accuracy, by shooting with one’s better hand.
I am a left-handed person. I chose to carry “primary” on my right hip, in 1983 or 1984, for several practical reasons, when I was training to become a police officer. So, carrying my snub-gun, as a second gun, in a lefty holster, was not for purposes of “weak hand” access, was it?