As far as I understand this topic, a bullet fired from a handgun (regardless of design) is usually only able to damage tissue by directly hitting and crushing it. Temporary cavitation is usually irrelevant to the wound profile. With a bullet fired from a high powered rifle on the other hand, the much larger temporary cavitation may in fact damage tissue by stretching and ruptering it. (I`m aware of the fact, that this effect depends on jawing, fragmentation or deformation of the bullet.)
The reason for this becomes obvious, if I compare a 124gr 9mm bullet traveling at about 330m/s and with about 450 Joule of energy to a 62gr 5,56mm bullet traveling at about 920m/s and with about 1.700 Joule of energy. The rifle has nearly 3 times the velocity and nearly 4 times the energy of the handgun.
So far so good. But where is the point, at which a bullet gets the potential to be so much more devastating? Is it a matter of energy (for example more than 1.000 Joule)? Is it a matter of velocity (for example more than 700m/s)? Or is there another mechanism, of which I`m unaware?