What pistol, assuming common defensive caliber's, would you choose for an extended shooting session, such as a high volume course over a relatively short period of time? This assumes a basically stock pistol, and not one that has been significantly recontoured, though replacing grip panels or other minor control changes are OK.
Take into account things like felt/perceived recoil, "Glock knuckle", HK trigger trough pinch, lots of reloads with a single stack like a 1911, lots of decocking with a SIG or Beretta TDA, etc.
In addition, if there is a pistol you otherwise really like, but has some comfort oddity, please feel free to comment on that feature.