I just now saw Stephanies' post about older Colts and timing issues. That is correct. And the smaller frame revolvers like the Detective Special seemed to have even more timing issues than the larger frame guns. The Colt hand hits each cylinder ratchet "dead on" and is held in that position until the trigger is released upon firing. This upward pressure forces the cylinder notch against the cylinder stop. This bank vault tightness instead of bringing about perfect chamber to barrel alignment may cause the alignment to be off the same amount in each chamber. This rigidity and the pressure required to maintain it are two primary causes of timing issues because this system accelerates wear. With older Colts, one part affects the next part and so on. For this reason they are more difficult to fine tune. Fine tuning includes timing.
Colt has endured various crises since WW2. Labor problems are one. Poor leadership is another. Colt quality control has had its many ups and downs throughout the years. The older revolvers cost too much to make. They were labor intensive. Years ago I read an NRA article written by a Colt retired master fitter. He said that double action revolver fitters were given a frame with barrel and cylinder and yoke fitted to it. From that point and within one hour, a master fitter could put together and fit 4 regular revolvers like the Official Police. The same fitters could put together 3 Pythons in the same time. Tools were lead bar, files, and stones. I would guess that files were used more than stones. The lead bar was the big hammer.
Most here came along after the demise of the general gunsmith. Many of these guys could repair the entire line of Colt and S&W revolvers along with every other shotgun and rifle sold in America. If they had not been able to, they would have starved. The older Colt action would not have been a mystery to them. I've heard several say that they preferred working on Smiths rather than Colts because the Smiths were simpler.
In bullseye target shooting the Colt Officer's Match reigned supreme. Men and women who shot Colts would not have considered shooting a Smith. At least that's what a local trooper told me in the early 1960's after he won the Nat'l Pistol Championship with one. My opinion is that a properly fitted older Colt would satisfy mine and your requirements about timing. Many of these fine revolvers have slipped through my hands over the years. I regret that.