When I bought my Omega and Saker 5.56 the idea was to be able to mount on several different rifles that I have.
I contacted SilencerCo about mounting the Saker 5.56 I my 22-250 and they said I would be better off using the Omega because it would handle the muzzle pressures of the 22-250. They weren't too keen on my using the Saker on the 22-250.
You might want to check with the MFG before investing in a 5.56 can for the 22-250. 22-250 produces a fair amount of muzzle pressure that the 5.56 suppressors may not handle. And, 5.56 suppressors are usually 1/2x28 thread.
Just my .02 worth.