The 45 Super is a great round ... With fullpower loads with my 20 & 29 I use 22# RSA ...
I have owned Glocks for 25 years now .. Grip angle is perfect for me now ( not at first ) I own 12 Glocks ... Im sorta use to them .... Glock 20's and 29's are better price options VS 10mm 1911's and some other steel framed options ....
The polymer frame not only makes it lighter but also dampens tbe recoil... Or it seems that way when I fire my buddies RIA 10mm .. I would be hesitant about running a steady diet of UW 10mm through any semiauto without having a stouter RSA ....
I have a 21 C and I have ran a few hundred rounds of 45 Super through it , with a 20# RSA ...and quite of bit of +P
My carry load for my 21C is UW 230gr +P with Nolser JHP
My 30S & 36 is standard pressure 230gr Remington Golden Sabers
You mentioned a 357M , im thinking you are referring to the 357 magnum, which is another fine round !!!
I carry a Ruger Security Six 4 inch barrel on occasion .. When I used to carry in the woods or trail I carried UW 357mag 158gr Gold dot ... and in my LCR357 for social work I carry Hornady 125gr FTX
For woods carry I carry my Glock 20 with UW 200gr XTP
My Glock 32 has taken over for my Security Six for SD carry .. My carry ammo for my 32 is Underwood 125gr Gold dot ..Higher capacity lighter weight and pretty much memics the "one shot drop " of the 125gr 357 magnum..
They are alot of options in the Glock line up , or at least with mine ... My 27 is my EDC loaded with 180gr HST