I started with Weaver in the 60's/70's as a kiddo, moved to ISO 80's, modern-ISO in the 90's. Watching Sevigny's elbows in vids and at Conyers GSSF and tried to adopt and hated it.
Then a couple years ago a shooter (@BES) gave me some F2F coaching tips on it and it took. It's a big help for me. I don't have a super strong grip and it helps with support hand leverage and pressure IMO.
I used to get so much Glock slide bite I'd use pic of my bloody web of my hand as an avatar. But since this change in elbows with resulting leverage, the Glock slide bite is gone.
I kinda miss it sometimes.
OTOH to @runcible 's point about wrist discomfort - on some days, I can get a stabbing sharp pain in the left wrist. Haven't noticed a pattern of why/when as weeks or months might separate bouts. Seems like it usually just stabs suddenly once at the end of a string as I release pressure. Don't know what's up with that.