The latest incident happened early Thursday around 8:30 a.m. in the 1400 block of South Pleasanton Road.
According to San Antonio Police Chief William McManus, the suspect had begun firing a handgun just south of East Southcross when he began to fire at a man on a bicycle near the bus.
McManus said the man on the bicycle looped behind the bus for cover, attempting to avoid as many as eight shots. There were three people onboard the bus at the time of the shooting, but no one was hurt.
McManus said officers were already in close proximity and responded within minutes.
As one officer pulled his vehicle over he experienced a flat tire, likely the result of gunfire, McManus said.
Gunfire was then exchanged by both the suspect and the officers, with the suspect being hit at least once. EMS was called to the scene.
The unidentified suspect was taken to an area hospital for his injuries. McManus said a motive for all the shooting remains unclear.
One officer had glass in his eye as as result of the incident and had to be treated by EMS crews.