I have noticed an increasing amount of interest in “the mountains of NC,” for the past several years. So, if buying, buy a big-enough piece of land, so it will still feel remote when the area gets loved to death by other like-minded folks. If there is a nice view that is dependent upon that hillside/mountainside remaining undeveloped, buy the whole hillside/mountainside, to the top.
Actually, this principal applies just about everywhere. We live on flat Gulf Coastal prairie, but our neighborhood is being changed by folks who knock-down the bungalows, and build McMansions, surrounded by high fences. We are about to lose our morning sun, and have to live with a view of an eight or ten feet of solid fence. The plants that attract the butterflies and hummingbirds, along the east side of our house, are going to fail to thrive, or die, if we do not move them. We are wondering whether to knock-down our bungalow, and build a modest multi-story house, or move to, well, somewhere like the mountains of NC or TN.
ETA: Take a look at the entire tax situation, and chose the state that is best for your individual situation. A few years ago, I drove to Piedmont, AL, to pick up a Bloodhound, from a lady who was downsizing her dog operation, after a move to AL, from FL, for tax reasons. (She had retired, and was also retiring from canine SAR volunteer work.) If I recall correctly, she and her husband carefully considered several states in the region, and chose to move to the mountains of northern AL.