All the personal experience and data I have on this says no. I wrecked a S&W M12 trying this many years ago with a less experienced gunsmith trying it with an almost new take off M10 3" barrel. The really knowledgeable gunsmiths I have discussed this type of project said no way they would try it.
With any of the alloy frame S&W revolvers (pre and post Scandium) the barrel torque in process at the factory the first time actually deforms and compresses the frame and partially cuts the threads making it difficult to impossible for another barrel to ever be installed and be tight. Pinned or not.
It was rather sickening to cut the ruined remains of the M12 frame on a bandsaw to dispose of it, but all it was good for after torquing out the barrel was to harvest the parts.