Some computer software can provide insight into your query, but you probably already know that. Already you and Malamute may be the forum's leading members on working up .44/.45 loads. I hesitate to give too much advice. Though experienced in the area, my views and approaches to arrive at load objectives are dated. For example, I would select a desired velocity level and match it with my chosen bullet. Then I would work up loads using Unique, Herco, and IMR 4227 and chronograph as I went. My knowledge of existing pressure data and awareness of which powder would be subject to pressure spikes would guide me and keep me out of trouble. Plus, I can read pressure signs. When I reached acceptable accuracy and velocity levels in a load that I deemed safe, I would not care if pressures were, for example, 16,000, 17,000, 19,000, or 20,000 psi. In modern .44 spl cases and in a modern revolver, it would not matter(to me)if the pressure range fell within the interval of 16,000 to 20,000 psi.
I may have more spare time than you. Let me also research your question in order to locate new data.